Centers and Institutes   |
Understanding the role of dietary carcinogens in the development of human cancer; potential for cancer chemoprevention through dietary interactions; and developing methods to investigate environmental exposure in single cells. Her research interests focus on understanding the role of dietary carcinogens in the development of human cancer, the potential for cancer chemoprevention through dietary interactions, and developing methods to investigate environmental exposure in single cells. Kris’ recent projects include 1) investigating the metabolism of food carcinogens in humans, 2) developing laboratory-based methods to measure the effect of digestion on carcinogen bioavailability, 3) understanding the effects of complimentary and alternative medicines using cell and animal models, 4) determining the role of the estrogen receptor in breast carcinogenesis and 5) developing methods to image the chemical composition of single mammalian and microbial cells using Time-of-Flight Secondary Ion Mass Spectrometry. Kris believes that these projects have been made more exciting, productive, and ultimately successful by indispensable collaborations with computer scientists, structural biologists, chemists and physicists.
Bennett, L. M., J. M. Montgomery, S. M. Steinberg, K. S. Kulp, “Flor-Essence® Herbal Tonic promotes mammary tumor development in Sprague Dawley rats” Breast Cancer Research and Treatment 88:87-93 (2004).
Quong, J. N., M. G. Knize, Kulp, K. S., K. J. Wu, “Molecule specific imaging analysis of carcinogens in breast cancer cells using time-of-flight secondary ion mass spectrometry,” (2004).
Kulp, K. S., M. G. Knize, N. Fowler, C. P. Salmon, and J. S. Felton, “PhIP metabolites in human urine after the consumption of well-cooked chicken,” Journal of Chromatography B 802: 143-153 (2004).
Kulp, K. S., S. L. Fortson, M. G. Knize and J. S. Felton, “An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix,” Food and Chemical Toxicology 41:1701-1710 (2003).
Kulp, K. S., M. G. Knize, M. A. Malfatti, C. P. Salmon, and J. S. Felton, "Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) following consumption of a single cooked chicken meal in humans," Carcinogenesis 21:2065-2072 (2000).